Green Synthesis of Biocompatible Chiral Gold Nanoparticles

被引：0
|
作者：
Fan, Yuan [1 ,2 ,3 ]
Li, Na [2 ]
Wang, Jiaolong [1 ,2 ]
Liao, Lan [1 ,2 ]
Wei, Junchao [1 ,2 ,3 ]
机构：
[1] School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang,330006, China
[2] Jiangxi Province Key Laboratory of Oral Disease, Nanchang,330006, China
[3] Jiangxi Province Clinical Research Center for Oral Disease, Nanchang,330006, China
来源：
Polymers | 2024年 / 16卷 / 23期
关键词：
Chiral gold nanoparticles (Au NPs) have been investigated widely and have shown great potential in biomedical applications; such as biosensing; combating bacterial infections and tissue regeneration. However; some stabilizers and reducing agents for the synthesis of chiral Au NPs can produce toxicity in living organisms. Therefore; it is interesting to design green methods to prepare chiral gold nanoparticles that are nontoxic; environment-friendly; and low-cost. Herein; novel biocompatible chiral Au NPs with a diameter of 54.4 ± 14.9 nm were prepared by the in situ reduction of HAuCl4 with alginates as the green reducing agent and chiral-inducing and stabilizing agent. XPS; TGA; UV-Vis and CD analyses demonstrated that alginate-stabilized chiral Au NPs (ALG-Au NPs) were successfully prepared; while biocompatibility assessment showed that cell viability was 116.0% when the concentration of ALG-Au NPs arrived at 300 μg/mL; which indicated that ALG-AuNPs showed excellent biocompatibility. Furthermore; the ALG-Au NPs can respond to metal ions; such as Ca2+; Cu2+; Mn2+ and so on; implying potential application for biosensing. © 2024 by the authors;
D O I：
10.3390/polym16233333
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