Inhibitory effects of phenylpropionamides from the hemp seed husk on tyrosinase

被引：1

作者：

Kim, Jang Hoon ^{[1
]}

Han, Kyung-Sook ^{[1
]}

Lee, Eun-Song ^{[1
]}

Kim, Yong-Goo ^{[1
]}

Kim, Yong-Il ^{[1
]}

Cheon, Jae-Young ^{[2
]}

Jung, Hyun-Ju ^{[2
]}

Kim, Ki Mo ^{[3
]}

Lee, Ik Soo ^{[3
]}

机构：

[1] RDA, Natl Inst Hort & Herbal Sci, Dept Herbal Crop Res, Eumsung 27709, Chungbuk, South Korea

[2] Wonkwang Univ, Wonkwang Oriental Med Res Inst, Dept Oriental Pharm, Iksan 570749, South Korea

[3] Korea Inst Oriental Med, KM Convergence Res Div, Daejeon, South Korea

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 282卷

关键词：

Tyrosinase; Hemp seed husk; Phenylpropionamides;

D O I：

10.1016/j.ijbiomac.2024.136939

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tyrosinase is an enzyme involved in melanin production. To identify inhibitors of this enzyme in natural products, extracts and fractions of hemp seed husk were screened for tyrosinase inhibition. Phenylpropionamides 1-9, which were isolated from the ethyl acetate fraction, had inhibitory effects; compounds 3 and 4 had the greatest inhibitory effects. Cannabisin A (3) was a non-competitive and cannabisin B (4) was a competitive inhibitor. The binding sites and interactions of each inhibitor on tyrosinase were calculated by computational chemistry. Potential inhibitor 3 decreased the melanin content and tyrosinase activity in B16F10 melanoma cells. Therefore, cannabisin A (3) has potential as a tyrosinase inhibitor.

引用

页数：8

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