An injectable shape-adaptive hydrogel system for subconjunctival injuries: In situ and permanently releases rapamycin to prevent fibrosis via promoting autophagy

被引：1

作者：

Sun, Xue ^{[1
]}

Cui, Haohao ^{[1
]}

Li, Jingfan ^{[1
]}

An, Boyuan ^{[1
]}

Liu, Ruixing ^{[1
]}

Guo, Zhihua ^{[1
]}

Chu, Dandan ^{[1
]}

Geng, Xingchen ^{[1
]}

Cui, Bingbing ^{[1
]}

Zhu, Lei ^{[1
]}

Li, Jingguo ^{[1
]}

Li, Zhanrong ^{[1
]}

机构：

[1] Zhengzhou Univ, Henan Eye Hosp, Henan Prov Peoples Hosp, Peoples Hosp, Zhengzhou 450003, Peoples R China

来源：

MATERIALS TODAY BIO | 2025年 / 30卷

基金：

中国国家自然科学基金;

关键词：

Subconjunctival fibrosis; Rapamycin; In situ hydrogel; Autophagy; CORNEAL; THERAPY;

D O I：

10.1016/j.mtbio.2024.101380

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Subconjunctival fibrosis (SCF) is a common and refractory eye disease that is a serious threat to vision. The severe side effects of existing drugs and low drug bioavailability due to the ocular barrier are major challenges in SCF treatment. Hence, there is an urgent need to explore safer and more effective strategies for administering anti-SCF drugs. Herein, an injectable and adaptable hydrogel system containing the antifibrotic drug rapamycin was fabricated to address this complex need. This system possesses moderate mechanical properties, self-healing and shape-adaptive capabilities, injectability, and biosafety. It is designed to promote autophagy by modulating the PI3K/AKT/mTOR/WIPI2 pathway, thereby inhibiting SCF. In vivo experiments utilizing a rat subconjunctival injury model indicated that in situ administration of this hydrogel system effectively inhibited SCF. This system constitutes a promising method for promoting autophagy to protect against SCF, which will foster its widespread application for other fibrotic diseases.

引用

页数：15