Optimization of the synthesis conditions of products formed in arenesulfonylation of N-alkylated anilines

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[1] Kustova, T.P.
[2] Smirnova, E.G.
[3] Kochetova, L.B.
[4] Kalinina, N.V.
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| 1600年 / Izdatel'stvo Nauka卷 / 87期
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Fundamental kinetic aspects of the arenesulfonylation of N-alkylated anilines in aqueous-organic media; the nonaqueous component of which are alcohols; ethers; and acetonitrile were studied. It was shown that; with increasing fraction of water in the solvent; the reaction rate constant grows and the reactivity of N-alkyl anilines depends not only on the structure of the alkyl radical; but also on the content of water in the solvent. It was found that dimethyl sulfoxide has a catalytic effect on these processes. The strategy of choosing the medium in syntheses of biologically active sulfonyl derivatives of fatty-aromatic amines is discussed. A conclusion about the applicability of aqueous-organic media in the production technology of N-alkylated anilines is based on a calculation of the yield of their arenesulfonylation products. © Pleiades Publishing; Ltd; 2014. Original Russian Text © T.P. Kustova; E.G; Smirnova; L.B; Kochetova; N.V; Kalinina; 2014;
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