High-affinity, small-molecule peptidomimetic inhibitors of mll1/wdr5 protein-protein interaction

被引：0
|
作者：
机构：
[1] [1,2,Karatas, Hacer
[2] Townsend, Elizabeth C.
[3] Cao, Fang
[4] 4,Chen, Yong
[5] 2,Bernard, Denzil
[6] 2,Liu, Liu
[7] 4,Lei, Ming
[8] Dou, Yali
[9] 1,2,5,Wang, Shaomeng
来源：
Wang, S. (shaomeng@umich.edu) | 1600年 / American Chemical Society卷 / 135期
关键词：
Cell death;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Journal article (JA)
引用
收藏
相关论文
共 50 条
  • [1] High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein-Protein Interaction
    Karatas, Hacer
    Townsend, Elizabeth C.
    Cao, Fang
    Chen, Yong
    Bernard, Denzil
    Liu, Liu
    Lei, Ming
    Dou, Yali
    Wang, Shaomeng
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (02) : 669 - 682
  • [2] Discovery of a potent MLL1 and WDR5 protein-protein interaction inhibitor with in vivo antitumor activity
    Chen, Weilin
    Chen, Xin
    Li, Dongdong
    Wang, Xianghan
    Long, Guanlu
    Jiang, Zhengyu
    You, Qidong
    Guo, Xiaoke
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 223
  • [3] The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction
    Ye, Xiaoqing
    Chen, Gang
    Jin, Jia
    Zhang, Binzhong
    Wang, Yinda
    Cai, Zhenhai
    Ye, Fei
    CURRENT MEDICINAL CHEMISTRY, 2020, 27 (33) : 5530 - 5542
  • [4] High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction
    He, Shihan
    Senter, Timothy J.
    Pollock, Jonathan
    Han, Changho
    Upadhyay, Sunil Kumar
    Purohit, Trupta
    Gogliotti, Rocco D.
    Lindsley, Craig W.
    Cierpicki, Tomasz
    Stauffer, Shaun R.
    Grembecka, Jolanta
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (04) : 1543 - 1556
  • [5] Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
    Senisterra, Guillermo
    Wu, Hong
    Allali-Hassani, Abdellah
    Wasney, Gregory A.
    Barsyte-Loyejoy, Dalia
    Dombrovski, Ludmila
    Dong, Aiping
    Nguyen, Kong T.
    Smil, David
    Bolshan, Yuri
    Hajian, Taraneh
    He, Hao
    Seitova, Alma
    Chau, Irene
    Li, Fengling
    Poda, Gennadiy
    Couture, Jean-Francois
    Brown, Peter J.
    Al-Awar, Rima
    Schapira, Matthieu
    Arrowsmith, Cheryl H.
    Vedadi, Masoud
    BIOCHEMICAL JOURNAL, 2013, 449 : 151 - 159
  • [6] High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity
    Li, Dong-Dong
    Chen, Wei-Lin
    Wang, Zhi-Hui
    Xie, Yi-Yue
    Xu, Xiao-Li
    Jiang, Zheng-Yu
    Zhang, Xiao-Jin
    You, Qi-Dong
    Guo, Xiao-Ke
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 124 : 480 - 489
  • [7] Fragment screening for a protein-protein interaction inhibitor to WDR5
    Dennis, Matthew L.
    Morrow, Benjamin J.
    Dolezal, Olan
    Cuzzupe, Anthony N.
    Stupple, Alexandra E.
    Newman, Janet
    Bentley, John
    Hattarki, Meghan
    Nuttall, Stewart D.
    Foitzik, Richard C.
    Street, Ian P.
    Stupple, Paul A.
    Monahan, Brendon J.
    Peat, Thomas. S.
    STRUCTURAL DYNAMICS-US, 2019, 6 (06):
  • [8] Exploring the role of the MLL1 complex in leukemia by small molecule targeting of an essential protein-protein interaction
    Townsend, Elizabeth
    Dou, Yali
    FASEB JOURNAL, 2011, 25
  • [9] Fragment screening for a protein-protein interaction inhibitor to WDR5
    Peat, Thomas S.
    Dennis, Matthew
    Dolezal, Olan
    Newman, Janet
    Morrow, Ben
    Monahan, Brendon
    Foitzik, Richard
    Khoo, Poh Sim
    Stupple, Paul
    Street, Ian
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2018, 74 : A139 - A139
  • [10] The discovery and optimization of small molecule antagonists of the WDR5 MLL interaction
    Al-Awar, R.
    Al-Awar, R. S.
    Getlik, M.
    Smil, D.
    Bolshan, Y.
    Poda, G.
    Senisterra, G.
    Wu, H.
    Allali-Hassani, A.
    Wasney, G. A.
    Barsyte-Lovejoy, D.
    Dombrovski, L.
    Dong, A.
    He, H.
    Seitova, A.
    Chau, I.
    Li, F.
    Couture, J. F.
    Kuznetsova, E.
    Marcellus, R.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : 95 - 95
12345