Efficacy of silver nanoparticle-modified bullfrog skin as an antimicrobial wound dressing

This research explores the synthesis of silver nanoparticles and their incorporation into bullfrog skin for potential use as a wound dressing. The study addresses the need for wound dressings that exhibit biocompatibility, low cytotoxicity, superior biodegradability, and antimicrobial activity. Silver nanoparticles were synthesized using silver nitrate and sodium citrate solutions and integrated into bullfrog skin at varying concentrations (0%, 0.5%, 1%, and 1.5%). The modified and unmodified bullfrog skin samples were characterized using dynamic light scattering(DLS), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDS). Antimicrobial analyses were conducted to assess the efficacy of the modified skin against common pathogens, including Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. The results demonstrated that samples containing 1% and 1.5% silver nanoparticles exhibited significant inhibitory effects on all tested microorganisms. This indicates that these concentrations are optimal for antimicrobial activity, suggesting the potential of silver nanoparticle-modified bullfrog skin as an innovative and effective wound dressing material. © 2024 Elsevier B.V.