Preparation and Drug Release of Redox/pH Dual-Responsive Bagasse Cellulose-Based Hydrogels

被引：0
|
作者：
Yang K. [1 ]
Pan Y. [1 ]
Cai P. [2 ]
Wang F. [3 ]
机构：
[1] Guangxi Key Lab of Petrochemical Resource Processing and Process Intensification Technology, College of Chemistry and Chemical Engineering, Guangxi University, Nanning
[2] College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou
[3] Asset Management Co., Ltd., Guangxi University, Nanning
来源：
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2021年 / 37卷 / 10期
关键词：
Drug release; Dual-responsive; Hydrogel; Sugarcane bagasse; Tetracycline hydrochloride;
D O I：
10.16865/j.cnki.1000-7555.2021.0266
中图分类号：
学科分类号：
摘要：
In order to prepare redox/pH responsive hydrogels, sugarcane bagasse cellulose was used as raw material and dissolved in N, N-dimethylacetamide/lithium chloride (DMAc/LiCl) solvent system. The as-prepared cellulose was then coupled with tert-butyl acetoacetate (t-BAA) via catalytic transesterification to obtain bagasse cellulose acetoacetate (BCAA), followed by reacting with cystamine dihydrochloride (CYS) to generate dual-responsive hydrogels. The results of FT-IR and SEM demonstrate the successful incorporation of enamine and disulfide bonds in the hydrogels and porous structure. The stability and water retention tests show that the hydrogels are stable and have a definite water retention under physiological conditions. Moreover, the drug release behaviors of hydrogels were studied under conditions of different redox and pH using tetracycline hydrochloride (TH) as model drug. The results indicate that both redox and pH conditions could control the drug release of hydrogels. Meanwhile, the drug-loaded hydrogel exhibits a excellent antibacterial activity against a broad spectrum of bacteria, i.e, both S.aureus and E.coli. Therefore, the redox/pH dual-responsive hydrogels developed in this work have great potential in the applications associated with drug release. © 2021, Editorial Board of Polymer Materials Science & Engineering. All right reserved.
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页码：145 / 152
页数：7
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