HFIP-promoted Michael reactions: direct para-selective C-H activation of anilines with maleimides

被引：0
|
作者：
Li B. [1 ]
Mao Q. [1 ]
Zhou J. [2 ]
Liu F. [1 ]
Ye N. [1 ]
机构：
[1] Department of Medicinal Chemistry, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, 215123, Jiangsu
[2] Department of Pharmacology and Toxicology, Center for Addiction Research, University of Texas Medical Branch, Galveston, 77555, Texas
来源：
Organic and Biomolecular Chemistry | 2019年 / 17卷 / 08期
基金：
中国国家自然科学基金;
关键词：
63;
D O I：
10.1039/C8OB03073A
中图分类号：
学科分类号：
摘要：
The Michael reaction is widely used for the C-C coupling of electron-poor olefins and C(sp 3 )-H pronucleophiles. Herein, an effective Michael reaction approach between electron-rich aromatic and heteroaromatic substrates as C(sp 2 )-H nucleophiles with maleimides as electrophiles in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was first presented without the need for any additional metal catalysts or reagents. This reaction provides a concise and environmentally friendly strategy for the facile construction of 3-aryl succinimides from N,N-disubstituted anilines and maleimides with high para selectivity. © The Royal Society of Chemistry.
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收藏
页码：2242 / 2246
页数：4
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