Novel highly selective quinoline-based fluorescent chemosensors for quantitative analysis of Cu(II) ion in water and food

While copper (Cu2+) is a vital cofactor in numerous enzymatic processes, its homeostasis is critical. Selective sensors for Cu2+ in food matrices are paramount for ensuring adherence to safety regulations and dietary interaction studies. In this work, novel derivatives of 8-aminoquinoline (L1-L4) with extended π-conjugation and various N-substituents were synthesized and evaluated as fluorescent sensors for Cu2+. The 2-pyridinecarbonyl-substituted derivative L3 exhibited sharp fluorescence quenching selectively in the presence of Cu2+. This compound presents high selectivity for Cu2+ even in the presence of other metal ions. The L3-based fluorescent sensor provides a Cu2+ detection limit of 77 nM, surpassing many existing sensors. The quantifications of Cu2+ in water, food supplements, and wines using this sensor have demonstrated good agreement with those obtained using the standard ICP technique. Notably, L3 also facilitates Cu2+ detection in microliter sample volumes at subnanomole levels using paper-based sensors, opening doors for portable and cost-effective on-site testing. © 2024 Elsevier B.V.