The Lujing ore field is located in the southwest of the Taoshan-Zhuguang uranium metallogenic belt. Besides the Lujing deposit, tens of other uranium deposits also occur in this ore field, such as the Huangfengling and Gaoxi. The Lujing ore field is one of the most important granite type uranium ore field in China. The NE-trending QF2 fault is one of the mineralizing control faults in the Lujing uranium ore field. The Huangfengling, Xiadongzi and Gaoxi deposits occur along this fault. In this paper, the geological characteristics of the QF2 fault and its relationship with uranium mineralization are studied by analyzing the surface characteristics of the fault and alternation zoning revealed by drilling holes. The results show that the QF2 fault have five stages of pulsating activities. The first stage of the activities was the formation of the massive quartz via tensional stress during the early Early Cretaceous. In the second stage, the lamprophyre dikes were formed by the upwelling of deep mantle materials along the fault. In the third stage, the strong compression led to the formation of the silicified breccia and the fault gouge. In the fourth stage, ascending of the deep fluid formed the hematite granite cataclastic rock and the cataclastic granite during the late Cretaceous. In the fifth stage, the loose breccia was formed in the extensional tectonic environment during Neogene or Quaternary. There are two or more stages of uranium mineralization. The early stage uranium mineralization was formed during the transition of the extensional tectonic environment from the first stage to the second stage. The late stage uranium mineralization was formed under the extensional tectonic environment of the fourth stage. The silicified breccia and fault gouge, which formed in the third stage, screened the late stage uranium mineralization. The footwall of the fault with a thickness of about 200 m is an important prospecting area, nonetheless, special attention should be paid to the dislocation effects of the fifth stage faulting. © 2023 Science Press. All rights reserved.