Enantioselective Redox-Neutral Coupling of Aldehydes and Alkenes by an Iron-Catalyzed catch-Release Tethering Approach

被引：0
|
作者：
Li, Jing [1 ]
Preinfalk, Alexander [1 ]
Maulide, Nuno [1 ]
机构：
[1] Institute of Organic Chemistry, University of Vienna, Währinger Strasse 38, Vienna,1090, Austria
来源：
Journal of the American Chemical Society | 2019年 / 141卷 / 01期
关键词：
Carbonyl addition - Diastereoselective alkylation - Emerging technologies - Enantio - Enantioselective - Functionalizations - Linear coupling - Reductive couplings;
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摘要：
The reductive coupling of aldehydes and alkenes is an emerging technology that holds the potential to reinvent carbonyl addition chemistry. However, existing enantioselective methods are limited to form branched products. Herein, we present a directed enantio- and diastereoselective alkylation of aldehydes with simple olefins to selectively yield linear coupling products. This is achieved by redox-neutral remote functionalization, whereby a tethering catch-release strategy decisively solves the key problems of reactivity and selectivity. © 2018 American Chemical Society.
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页码：143 / 147
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