Programmable sensors of 5-hydroxymethylcytosine

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[1] Kubik, Grzegorz
[2] Batke, Sabrina
[3] Summerer, Daniel
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Summerer, Daniel (daniel.summerer@uni-konstanz.de) | 1600年 / American Chemical Society卷 / 137期
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5-Hydroxymethylcytosine; (hmC); the sixth base of the mammalian genome; is increasingly recognized as an epigenetic mark with important biological functions. We report engineered; programmable transcription-activator-like effectors (TALEs) as the first DNA-binding receptor molecules that provide direct; individual selectivities for cytosine (C); 5-methylcytosine; (mC); and hmC at user-defined DNA sequences. Given the wide applicability of TALEs for programmable targeting of DNA sequences in vitro and in vivo; this provides broad perspectives for epigenetic research. © 2015 American Chemical Society;
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