Electrochemical 1,2-hydrogen atom transfer functionalizations of N-(benzyloxy)phthalimides

被引：1
|
作者：
Fu, Xin [1 ]
Ran, Tingting [1 ]
Liu, Jie [1 ,2 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China
[2] Hunan Univ, Greater Bay Area Inst Innovat, Guangzhou 511300, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 23期
基金：
中国国家自然科学基金;
关键词：
C-H FUNCTIONALIZATION; HYDROGEN-ATOM; ALKOXYL RADICALS; SELECTIVE FUNCTIONALIZATION; ORGANIC ELECTROSYNTHESIS; C(SP(3))-H BONDS; OXIDATION; HETEROARYLATION; REARRANGEMENT; REACTIVITY;
D O I：
10.1039/d4qo01607f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a straightforward, catalyst-free method for the cathodic benzylic C-H hydroxyalkylation/arylation of N-(alkyloxy)phthalimides with ketones or cyanopyridines. The reaction is driven by an electrochemically induced 1,2-hydrogen atom transfer involving alkoxy radicals generated by O-N bond cleavage. This protocol provides an efficient approach for the synthesis of a wide range of valuable unsymmetrical 1,2-diols and diarylmethanols.
引用
收藏
页码：6760 / 6767
页数：8
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