Pluronic Micelles Used to Load and Release of the Anticancer Drug Doxorubicin

In order to study the existing form of doxorubicin micelles and its relationship with the release behavior of micelles, three types of Pluronic micelles were used as carrier material to prepare three kinds of doxorubicin F127, F128, F68 and F108 micelles. The Pluronic drug-loaded micelles were first formed by doxorubicin hydrochloride and sodium deoxycholate through electrostatic interactions to form the complexes, and then formed by hydrophilic and hydrophobic encapsulation to the hydrophobic segments of Pluronic micelles. The drug loading capacity and encapsulation rate were used as evaluation indicator. The particle size and distribution were determined by dynamic light scattering method, and the in vitro release behavior of drug-loaded micelle was determined by dialysis method. The results show that the drug loadings of the prepared Pluronic F127, F128 and F68 micelles are (0.15±0.1)%, (0.16±0.07)% and (0.17±0.1)%, encapsulation rates are (3.03±0.24)%, (3.11±0.147)% and (3.36±0.024)%. The particle size distribution of the drug-loaded micelles is uniform. The cumulative release rate can reach more than 70% within 690 min, with no significant difference. This study shows that uniform and stable Plantronics-loaded micelle were been successfully prepared. There is no significant difference in the release behavior of different Plantronics-loaded micelles. ©2021, Editorial Board of Polymer Materials Science & Engineering. All right reserved.