Development of an impurity and hydrate form controlling continuous crystallization to telescope a two-step batch recrystallization in the GDC-4379 drug substance process

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作者
Morris, Gary [1 ]
Keogh, Aaron P. [2 ]
Farid, Umar [2 ]
Stumpf, Andreas [3 ]
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[1] Engineering, APC Ltd., Building 11, Cherrywood Business Park, Loughlinstown,Co. Dublin, Ireland
[2] Chemistry, APC Ltd., Building 11, Cherrywood Business Park, Loughlinstown,Co. Dublin, Ireland
[3] Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco,CA,94080, United States
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摘要
Batch data processing
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页码:608 / 622
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  • [1] Development of an impurity and hydrate form controlling continuous crystallization to telescope a two-step batch recrystallization in the GDC-4379 drug substance process
    Morris, Gary
    Keoghb, Aaron P.
    Farid, Umar
    Stumpf, Andreas
    CHEMICAL ENGINEERING RESEARCH & DESIGN, 2022, 183 : 608 - 622