Preparation and characterization of injectable nHA/PU composite porous scaffolds for bone repair

被引：0
|
作者：
Li G. [1 ,2 ]
Li J. [2 ]
机构：
[1] Medical Department, Xizang Minzu University, Xianyang
[2] Research Center for Nano-Biomaterial, Sichuan University, Chengdu
来源：
Huagong Jinzhan/Chemical Industry and Engineering Progress | 2021年 / 40卷 / 12期
关键词：
Bone repair; Injectable; Nano-hydroxyapatite; Polyurethane; Porosity;
D O I：
10.16085/j.issn.1000-6613.2021-0045
中图分类号：
学科分类号：
摘要：
Bone defect repair still represents a challenging issue in clinic. Injectable composite materials for bone repair with good porosity and in situ solidification of arbitrary shape have shown great advantages in the treatment of clinical irregular bone defects. In this study, injectable porous nano hydroxyapatite/polyurethane (nHA/PU) composite scaffolds were fabricated with two-component design and using water as foaming agent. Furthermore, the morphology, chemical composition, internal structure, mechanical properties and curing time of the fabricated scaffold were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), X ray diffraction (XRD), mechanical testing and Gilmore needle testing. The results showed that the injectable nHA/PU composite porous scaffolds were successfully prepared. The scaffolds had high porosity and good pore connectivity. The pore size distribution was 100-700μm, which was suitable for the growth of cells and tissues into the pores. The addition of 20% nHA significantly improved the mechanical strength of the PU porous scaffolds but reduced the porosity of the scaffolds. The injectable scaffolds solidified in 8h, which was suitable for clinical operation. The injectable nHA/PU composite porous scaffold prepared in this study has great potential in the field of irregular bone defect repair. © 2021, Chemical Industry Press Co., Ltd. All right reserved.
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页码：6800 / 6806
页数：6
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