Screening of Highly Hazardous Pollutants in Groundwater of Beijing

被引：0
|
作者：
Yang L. [1 ]
Xu Y. [1 ]
Yu S.-H. [1 ]
Li X.-F. [1 ]
Li J. [1 ]
机构：
[1] Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, College of Water Sciences, Beijing Normal University, Beijing
来源：
Huanjing Kexue/Environmental Science | 2024年 / 45卷 / 06期
关键词：
absorption; and excretory（ADME）; compound screening; distribution metabolism; groundwater pollution; hydrophobic organic contaminants（HOCs）; non-targeted screening techniques; toxicological priority index（Tox Pi）;
D O I：
10.13227/j.hjkx.202305019
中图分类号：
学科分类号：
摘要：
Groundwater contaminants pose a great threat to water safety and human health. Therefore，in this study，the traditional hazard assessment method was improved and a comprehensive system covering hazard assessment，screening，and characterization by combining the toxicological priority index（Tox Pi）framework；absorption，distribution，metabolism，and excretory（ADME）analysis；and bipartite network analysis was constructed. Then，the system was applied to hazard assessment and toxic pollutants screening from the 234 hydrophobic organic contaminants（HOCs）identified in the groundwater of Beijing. First，the top 20 pollutants with hazard potential were screened out using the Tox Pi method. Subsequently，17 high-priority HOCs were further identified based on the ADME property analysis. Then，the molecular targets of these 17 high-priority HOCs were characterized through systematic bipartite network analysis. Finally，ten HOCs with high hazard were screened through correlation and weighted average analysis，and it was revealed that their toxic effects were mainly concentrated in the endocrine-disrupting effect，carcinogenic effect，and genetic toxicity. This study provides technical support for the prevention of regional groundwater contaminants. © 2024 Science Press. All rights reserved.
引用
收藏
页码：3142 / 3152
页数：10
相关论文
共 54 条
  • [1] Ren J，, Li J，, Xi B D，, Et al., Groundwater pollution prevention and control in China：current status and countermeasures［J］, Strategic Study of CAE, 24, 5, pp. 161-168, (2022)
  • [2] Han Y T, Liu C, Mi Z X，, Et al., Bibliometric analysis of patents for groundwater pollution remediation technology in China ［J］, Environmental Protection Science, 48, 6, pp. 86-92, (2022)
  • [3] D'Agostino F，, Avellone G，, Ceraulo L，, Et al., Groundwater of sicily （Italy） close to landfill sites： quality and human health risk assessment ［J］, Exposure and Health, 13, 3, pp. 535-550, (2021)
  • [4] Li J, Jiang Y H，, Et al., Nongenomic effects and mechanistic study of butyl benzyl phthalate-induced thyroid disruption：based on integrated in vitro，in silico assays and proteome analysis［J］, Science of the Total Environment, (2022)
  • [5] Zhang B C, Zhang L P, Wang D W，, Et al., Non-targeted screening of trace organic pollutants in source water by GC × GC-TOFMS［J］, Environmental Chemistry, 42, 4, pp. 1109-1117, (2023)
  • [6] Mao J D, Yu N Y, Yu H X，, Et al., Research process of the high-throughput screening for identification of environmental organic pollutants［J］, Environmental Chemistry, 39, 1, pp. 156-165, (2020)
  • [7] Lu X Y, Wang F，, Zhang L M，, Et al., Nontarget screening and ecological risk assessment of polar organic pollutants in surface water on the West bank of Taihu Lake［J］, Environmental Science, 42, 11, pp. 5284-5293, (2021)
  • [8] Liu Q Z，, Xu X，, Lin L H，, Et al., Occurrence，distribution and ecological risk assessment of polycyclic aromatic hydrocarbons and their derivatives in the effluents of wastewater treatment plants［J］, Science of the Total Environment, (2021)
  • [9] Zhang Y., Development of zebrafish model for comprehensive assessment of endocrine disruption based on hormone biomarkers and application in assessment for three fungicides［D］, (2020)
  • [10] Feng X X，, Sun H L，, Liu X，, Et al., Occurrence and ecological impact of chemical mixtures in a semiclosed sea by suspect screening analysis［J］, Environmental Science & Technology, 56, 15, pp. 10681-10690, (2022)
123456