Pd/C-catalyzed regiodivergent hydrocarboxylation and esterification of alkynes

An unprecedented and highly reactive Pd/C catalytic system has been introduced for the regiodivergent hydrocarboxylation of terminal alkynes to selectively afford various acrylic and cinnamic acids employing oxalic acid as a CO source as well as a promoter for the formation of the active Pd-H complex. Herein, the formation of cinnamic acid is proposed to follow a unique anti-Markovnikov hydroiodination mechanism and the formation of acrylic acid might follow the traditional hydrocarboxylation pathway. Additionally, internal alkynes undergo hydrocarboxylation and carbonylative esterification with aliphatic alcohols to yield different alpha,beta-unsaturated acids and esters respectively. The designed strategies were successfully leveraged for a diverse class of alpha,beta-unsaturated acids and esters with excellent selectivity and yields under mild reaction conditions. Furthermore, the acid functionalization of complicated naturally derived alkynes, utilizing economical and bench-stable oxalic acid and a commercially accessible reusable catalyst with gram-scale applicability are the additional benefits of the established protocol. A Pd/C-catalyzed regiodivergent hydrocarboxylation of terminal alkynes to cinnamic and acrylic acids as well as hydroxy/alkoxy carbonylation of internal alkynes to alpha,beta-unsaturated acids/esters have been devised using oxalic acid as a CO source.