Functional Significance and Structure-Activity Relationship of Food-Derived Protein Tyrosine Phosphatase 1B Inhibitors

被引：0
|
作者：
Bao M. [1 ]
Wang Z. [1 ]
机构：
[1] School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin
来源：
Shipin Kexue/Food Science | 2023年 / 44卷 / 17期
关键词：
food-derived; natural compounds; protein tyrosine phosphatase 1B inhibitor; type; 2; diabetes;
D O I：
10.7506/spkx1002-6630-20220922-220
中图分类号：
学科分类号：
摘要：
Protein tyrosine phosphatase 1B (PTP1B), a potential target for the treatment of type 2 diabetes and obesity, plays a key negative regulatory role in the insulin and leptin signaling pathways. Natural products, with structural diversity, can affect different targets and pathways to exert their unique preventive and therapeutic effects on diabetes or its complications. Various food-derived natural products have been reported for their PTP1B inhibitory activity in recent years. This article mainly overviews recent progress in understanding the mechanism of action of PTP1B and food-derived natural PTP1B inhibitors, which will hopefully provide a theoretical rationale for further research on PTP1B inhibitors and the development of new PTP1B inhibitors or hypoglycemic functional foods. © 2023 Chinese Chamber of Commerce. All rights reserved.
引用
收藏
页码：258 / 267
页数：9
相关论文
共 67 条
  • [1] ASSOCIATION A D., 3. Foundations of care and comprehensive medical evaluation, Diabetes Care, 39, pp. S23-S35, (2016)
  • [2] Global report on diabetes WHO library cataloguing-in-publication data, pp. 21-26, (2016)
  • [3] IMAM K., Clinical features, diagnostic criteria and pathogenesis of diabetes mellitus, pp. 340-355, (2012)
  • [4] LIU G., Protein tyrosine phosphatase 1B inhibition: opportunities and challenges, Current Medicinal Chemistry, 10, 15, pp. 1407-1421, (2003)
  • [5] AVRUCH J., Insulin signal transduction through protein kinase cascades, Molecular and Cellular Biochemistry, 182, 1, pp. 31-48, (1998)
  • [6] SALTIEL A R, KAHN C R., Insulin signalling and the regulation of glucose and lipid metabolism, Nature, 414, pp. 799-806, (2001)
  • [7] HUNTER T, SEFTON B M., Transforming gene product of Rous sarcoma virus phosphorylates tyrosine, Proceedings of the National Academy of Sciences of the United States of America, 77, 3, pp. 1311-1315, (1980)
  • [8] HUNTER T., Signaling-2000 and beyond, Cell, 100, 1, pp. 113-127, (2000)
  • [9] ZHANG Z., Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development, Annual Review of Pharmacology and Toxicology, 42, 1, pp. 209-234, (2002)
  • [10] ALONSO A, SASIN J, BOTTINI N, Et al., Protein tyrosine phosphatases in the human genome, Cell, 117, 6, pp. 699-711, (2004)
1234567