Characterization of the Oxazolone and Macrocyclic Motifs in the bn (n = 2-5) Product Ions from Collision-Induced Dissociation of Protonated Oligoglycine Peptides with Isomer-Selective, Cryogenic Vibrational Spectroscopy

被引：0

作者：

Mohamed, Ahmed ^{[1
]}

Rana, Abhijit ^{[1
]}

Perez, Evan ^{[1
,2
]}

Dahlmann, Franziska ^{[3
]}

Fry, Allison ^{[4
]}

Menges, Fabian S. ^{[1
]}

van Stipdonk, Michael ^{[4
]}

Jäger, Svenja ^{[5
]}

Boyer, Mark A. ^{[6
]}

McCoy, Anne B. ^{[7
]}

Johnson, Mark A. ^{[1
]}

机构：

[1] Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven,CT,06520, United States

[2] The University of Utah, 315 S. 1400 E. Rm 2020, Henry Eyring Bldg, Salt Lake City,UT,84112, United States

[3] Institut for Ion Physics and Applied Physics, University of Innsbruck, Technikerstraße 25, Innsbruck,6020, Austria

[4] Center of Excellence in Mass Spectrometry, Center for Metal Ions in Biological and Chemical Systems, Department of Chemistry and Biochemistry, Duquesne University, 600 Forbes Avenue, Pittsburgh,PA,15282, United States

[5] Chair of Physical Chemistry II, Ruhr-University Bochum, Universitätsstraße 150, Bochum,44801, Germany

[6] Department of Chemistry, University of Wisconsin-Madison, Madison,WI,53706, United States

[7] Department of Chemistry, University of Washington, Seattle,WA,98195, United States

来源：

Journal of the American Society for Mass Spectrometry | 1600年 / 35卷 / 02期

关键词：

Collision-induced dissociation (CID) of small; protonated peptides leads to the formation of b-type fragment ions that can occur with several structural motifs driven by different covalent intramolecular bonding arrangements. Here; we characterize the so-called oxazolone and macrocycle bn ion structures that occur upon CID of oligoglycine peptides (Gn) ions (n = 2-6). This is determined by acquiring the vibrational band patterns of the cryogenically cooled; D2-tagged bn ions obtained using isomer-selective; two-color IR-IR photobleaching and analyzing them with predicted (DFT) harmonic spectra for the candidate structures. Both oxazolone and macrocyclic isomers are formed by b4; whereas only oxazolone species are created for b2 and b3 and the macrocycle is created for b5. As such; n = 4 corresponds to the minimum size where both Oxa and MC forms are present. © 2023 American Society for Mass Spectrometry. Published by American Chemical Society. All rights reserved;

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摘要：

Journal article (JA)

引用

页码：326 / 332

共 2 条

[1] Characterization of the Oxazolone and Macrocyclic Motifs in the b n (n=2-5) Product Ions from Collision-Induced Dissociation of Protonated Oligoglycine Peptides with Isomer-Selective, Cryogenic Vibrational Spectroscopy
Mohamed, Ahmed
Rana, Abhijit
Perez, Evan
Dahlmann, Franziska
Fry, Allison
Menges, Fabian S.
van Stipdonk, Michael
Jaeger, Svenja
Boyer, Mark A.
McCoy, Anne B.
Johnson, Mark A.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2023, 35 (02) : 326 - 332
[2] TRANSLATIONAL SPECTROSCOPY OF N+ FRAGMENTS FROM 5 KEV COLLISION-INDUCED DISSOCIATION OF N-2+ IONS BY HELIUM
COMTET, G
FOURNIER, PG
LASSIERGOVERS, B
CHEMICAL PHYSICS, 1986, 101 (02) : 299 - 309

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