A giant macrocycle overcomes the post-treatment phototoxicity of photofrin through host-guest complexation

被引：0

作者：

Lin, Shujie ^{[1
]}

Yu, Xiang ^{[2
]}

Zhang, Ziliang ^{[1
]}

Zhang, Yahan ^{[1
]}

Chen, Junyi ^{[1
,2
]}

Li, Chunju ^{[2
]}

Meng, Qingbin ^{[1
]}

机构：

[1] State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing,100850, China

[2] Academy of Interdisciplinary Studies on Intelligent Molecules, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin,300387, China

来源：

Chemical Communications | 2024年 / 60卷 / 93期

关键词：

D O I：

10.1039/d4cc04777j

中图分类号：

O6 [化学]; TQ03 [化学反应过程]; TQ02 [化工过程（物理过程及物理化学过程）];

学科分类号：

0703 ; 081701 ; 081704 ;

摘要：

Here we reported a supramolecular sequestration strategy to overcome the post-treatment phototoxicity of photofrin via direct host-guest complexation. Efficient recognition potency of a giant pentaphen[3]arene derivative could favor suppressing sunlight-induced skin damage through weakening the ability of complexed photofrin to generate singlet oxygen. © 2024 The Royal Society of Chemistry.

引用

页码：13686 / 13689

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