Synthesis and pilot-scale process of L-selenium-methylselenocysteine

被引：0

作者：

Liao J. ^{[1
]}

Yang P. ^{[1
]}

Li Y. ^{[1
]}

Liu J. ^{[1
]}

Dai Y. ^{[1
]}

Zheng J. ^{[1
]}

Ou S. ^{[1
]}

Zhou H. ^{[1
]}

机构：

[1] Department of Food Science and Engineering, Jinan University, Guangzhou

来源：

Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities | 2023年 / 37卷 / 06期

关键词：

L-selenium-methylselenocysteine; L-selenocystine; reaction kinetics; reduction; synthesis;

D O I：

10.3969/j.issn.1003-9015.2023.06.010

中图分类号：

学科分类号：

摘要：

The synthesis of L-selenium-methylselenocysteine (L-SeMC) has problems of low safety factor and high cost of post-treatment. A new synthetic method was proposed in this study. Optimized process conditions were first obtained in laboratory, and then a pilot production line was designed and built to verify the process stability. The laboratory results show that L-serine is chlorinated to obtain 3-chloro-L-alanine hydrochloride (yield: 89.7%), and then reacts with sodium diselenide by sodium triacetoxyborohydride reduction to generate L-selenocystine(L-SeC2) (yield: 73.0%). The target product is finally obtained by reduction and methylation under the molar ratio of n(L-SeC2):n(iodomethane):n(sodium triacetoxyborohydride) =1.00:4.02:1.58 (yield:78.3%). The yields of the pilot production line are close to or higher than that of the laboratorial results, which helps for the industrial production of L-SeMC. © 2023 Zhejiang University. All rights reserved.

引用

页码：951 / 961

页数：10

共 34 条

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