Cost-effectiveness of a mathematical modeling with optimal control approach of spread of COVID-19 pandemic: A case study in Peru

COVID-19 pandemic affects 213 countries and regions around the world. Which the number of people infected with the virus exceeded 26 millions infected and more than 870 thousand deaths until september 04, 2020, in the world, and Peru among the countries most affected by this pandemic. So we proposed a mathematical model describes the dynamics of spread of the COVID-19 pandemic in Peru. The optimal control strategy based on the model is proposed, and several reasonable and suitable control strategies are suggested to the prevention and reduce the spread COVID-19 virus, by conducting awareness campaigns and quarantine with treatment. coronavirus 2019 (COVID-19). Pontryagin's maximum principle is used to characterize the optimal controls and the optimality system is solved by an iterative method. Finally, some numerical simulations are performed to verify the theoretical analysis using Matlab. © 2022