Rare-earth Upconversion Nanomaterials for Medical Magnetic Resonance Imaging

被引：0
|
作者：
Meng X.-F. [1 ]
Liu Y.-Y. [1 ]
Bu W.-B. [1 ]
机构：
[1] Shanghai Key Laboratory of Green Chemistry and Chemical Processes, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai
来源：
Faguang Xuebao/Chinese Journal of Luminescence | 2018年 / 39卷 / 01期
关键词：
Disease therapy; Magnetic resonance imaging(MRI); Multi-modality imaging; Upconversion nanoparticle;
D O I：
10.3788/fgxb20183901.0069
中图分类号：
学科分类号：
摘要：
Upconversion nanoparticle (UCNP) following anti-Stokes principle is a novel type of luminescence materials, which possesses many unique merits such as high luminescence intensity, luminous stability, no background fluorescence, no bleaching, low toxicity and good biocompatibility. The infrared or near infrared excitation light endows UCNP with deep penetration in living tissues for potential applications in biomedical detection, diagnose and treatment. Magnetic resonance imaging (MRI), as one of the commonly used techniques in clinical, has many special advantages like high quality of soft tissue imaging, high spatial resolution, no radiation and no damage, which plays a significant role in diagnosis of cardiovascular and cerebrovascular diseases. In this review, we focus on the recent researches in regard to rare-earth upconversion nanomaterials for MRI diagnosis and application. The mechanism of magnetic resonance imaging, the construction of MRI contrast agents, and the design and synthesis of UCNP-based multi-functional nanomaterials for MRI diagnosis and disease therapy have been introduced in detail, on the other hand, by means of the relevant researches reported by our group, which are based on UCNP for medical MRI and multimodal imaging, the prospects of UCNP in the application of MRI have also been discussed in this review. © 2018, Science Press. All right reserved.
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页码：69 / 91
页数：22
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