Design and fabrication of polymer film-based inertial microfluidic chips and particles focusing mechanisms in straight channels

被引：0
|
作者：
Jiang F. [1 ,2 ]
Xiang N. [1 ,2 ]
Ni Z. [1 ,2 ]
机构：
[1] Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing
[2] School of Mechanical Engineering, Southeast University, Nanjing
来源：
Dongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Southeast University (Natural Science Edition) | 2019年 / 49卷 / 04期
关键词：
Inertial focusing; Inertial microfluidic chip; Polymer film; Straight microchannel;
D O I：
10.3969/j.issn.1001-0505.2019.04.017
中图分类号：
学科分类号：
摘要：
A low-cost polymer-film inertial microfluidic chip with a simple straight channel was proposed. The effects of sample flow rate, particle size and channel cross-sectional dimension on particle focusing were systematically explored. By using the method of laser cutting and thermoplastic sealing, the microfluidic chips can be quickly and massively produced. The experimental results show that the particle focusing performance gradually enhances with increasing sample flow rate and then deteriorates after reaching the peak point. There are significant differences in the performance of particles focusing when particle sizes are different. The large particles are found to have better focusing performance than the small particles. The experimental results of microchannel with different cross-sectional widths show that smaller width channel is more beneficial for particle focusing. The proposed inertial microfluidic chip can provide the prospect of efficient pretreatment for biomedical applications. © 2019, Editorial Department of Journal of Southeast University. All right reserved.
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页码：736 / 741
页数：5
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