A 3D location method of bioluminescence light source based on multi-view projection surface reconstruction

被引：0
|
作者：
Ning, Nan-Nan [1 ]
Liu, Xia [1 ]
Deng, Ke-Xin [3 ]
Wu, Ping [2 ]
Wang, Kun [2 ]
Tian, Jie [2 ,3 ]
机构：
[1] School of Automation, Harbin University of Science and Technology, Harbin,150080, China
[2] Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing,100190, China
[3] School of Life Sciences and Technology, Xidian University, Xi'an,710126, China
来源：
Zidonghua Xuebao/Acta Automatica Sinica | 2014年 / 40卷 / 08期
关键词：
In bioluminescent tomography imaging (BLT); dual-modality fusion (optical modality and structural modality) can make full use of high accuracy 3D geometrical structures provided by structural modality reconstruct 3D surface light flux distribution and bioluminescence inner light source reconstruction. However; compared with the all-optical modality; dual-modality fusion has the problems of complicated fusion system; high cost compared with all-optical system; multifarious and exhaustive date processing; and ionizing radiation (for example; CT); Therefore; the 3D location method of bioluminescence light source based on pure optical 3D geometrical structures has significance for BLT. In this paper; we present a 3D location method of bioluminescence light source based on multi-view projection surface reconstruction; and an all-optical bioluminescence tomography system (AOBTS) is developed for this method. The method consists of 3D surface reconstruction based on multi-view optical projection; multi-view luminescent seamless integration; calibration and quantification of the surface light flux and internal bioluminescence reconstruction. An in-vivo BALB/C mouse with an implanted luminescent light source are used to evaluate the performance of the new method. Compared with the conventional optical methods; the new method improves not only the 3D surface reconstruction method but also the multi-view luminescent seamless integration. It has realized 3D real mouse bioluminescence light source localization; and the preliminary test proves its potential application in clinical trial. © 2014 Acta Automatica Sinica. All rights reserved;
D O I：
10.3724/SP.J.1004.2014.01793
中图分类号：
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页码：1793 / 1803
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