In order to analyze dynamic response characteristics of asphalt bridge deck pavement more accurately, a vehicle- road-bridge dynamic analysis method based on actual vehicle modeling was proposed to study dynamic behavior of asphalt bridge deck pavement under multi-vehicle load. Taking a steel-concrete I-shaped composite girder bridge as an example, considering effects of bridge vibration on deck pavement, the single vehicle-deck pavement coupled dynamic model was established through numerical simulation, and compared with the traditional model without considering coupling and moving load to verify the correctness of the coupling model and the necessity of considering coupling. Based on the single vehicle-deck pavement coupled model, dynamic response behavior of asphalt deck pavement under multi-vehicle load was studied. Stress and deflection responses of each layer of bridge deck pavement under double-vehicle in parallel and double- vehicle eccentric load conditions were analyzed, and compared with those under single vehicle conditions. The study results showed that eccentric load changes the direction of transverse stress of bridge deck pavement, tensile stress appears on top surface of asphalt layer and asphalt-concrete interface, so longitudinal cracks are easy to appear on top surface of asphalt pavement, and the maximum transverse tensile stress occurs on asphalt-concrete interface; the maximum longitudinal stress of bridge deck pavement occurs at asphalt-concrete interface; when two cars running in parallel, the longitudinal stress at asphalt-concrete interface increases by 52.7% compared with that during single vehicle running; shear stress is the maximum under eccentric load, it occurs at concrete-steel beam interface, and this interface is easy to separate, so anti-shear measures should be taken; largest deflections of different bridge deck pavements all occur under the condition of double-vehicle running in parallel, and their values can increase by 64% compared with those under single vehicle running condition; compared with action of single vehicle, considering coupling between multi-vehicle and bridge deck pavement should meet higher requirements for design and damage control of bridge deck pavement. © 2021, Editorial Office of Journal of Vibration and Shock. All right reserved.