Preparation and properties of curcumin dimer loaded nanoparticles

被引：0
|
作者：
Wen N. [1 ]
Liu Z. [2 ]
Du P. [1 ]
Hou J. [1 ]
Liu Y. [1 ]
机构：
[1] School of Chemistry and Chemical Engineering, Central South University, Changsha
[2] Xiangya School of Pharmaceutical Sciences, Central South University, Changsha
来源：
Zhongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Central South University (Science and Technology) | 2020年 / 51卷 / 09期
关键词：
Curcumin dimer; Drug delivery system; Nanoparticles; PEG-PLGA;
D O I：
10.11817/j.issn.1672-7207.2020.09.003
中图分类号：
学科分类号：
摘要：
In order to improve the drug loading efficiency of antitumor drug curcumin, a new curcumin dimer (CUR2-TK) was synthesized using curcumin as a unit, and polyethylene glycol-polylactic acid-glycolic acid copolymer (PEG-PLGA ) used as a carrier, curcumin dimer loaded sustained-release nanoparticles were prepared by a single emulsion solvent volatilization method, and the effects of different experimental conditions such as the mass ratio of different drugs to polymer (m(CUR2-TK): m(PEG-PLGA)) on the performance of nanoparticles were studied. The results show that the drug-loaded nanoparticles constructed by curcumin dimer have extremely high drug-loading efficiency. Under the condition of m(CUR2-TK): m(PEG-PLGA)=3:1, the drug load and entrapment efficiency reaches (61.9 ± 2.9)% and (80.1 ± 3.8)%, respectively, and the nanoparticles are uniform in appearance and the particle size can be controlled between 50 and 100 nm. The drug release of the nanoparticles is up to 4 d. © 2020, Central South University Press. All right reserved.
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页码：2389 / 2395
页数：6
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