Mechanical force modulates beta-catenin intracellular signaling activity

被引：0
|
作者：
Avvisato, Chris [1 ]
Tozeren, Aydin [1 ]
Byers, Stephen W. [1 ]
机构：
[1] Catholic Univ of America, Washington, United States
来源：
Annals of Biomedical Engineering | 2000年 / 28卷 / SUPPL. 1期
关键词：
Biomechanics - Cells - Enzymes - Hemodynamics - Laminar flow - Proteins - Shear flow;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Beta-catenin is a key signal transduction protein in the wnt signaling pathway that controls embryonic body patterning and cancer. Beta-catenin signaling activity in colon and breast carcinoma cells was examined to study the effect of shear stress. Beta-catenin signaling activity decreased as exposure to shear flow increased in time from 0,3,6, and 12 hrs. Transfection of cells with dominant-negative kinases (IKKs) reversed the shear stress-induced decrease in beta-catenin signaling activity.
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