NMR-based metabolomic investigation of bioactivity of chemical constituents in black raspberry (Rubus occidentalis L.) fruit extracts

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[1] [1,Paudel, Liladhar
[2] Wyzgoski, Faith J.
[3] Giusti, M. Monica
[4] 4,Johnson, Jodee L.
[5] Rinaldi, Peter L.
[6] Scheerens, Joseph C.
[7] Chanon, Ann M.
[8] Bomser, Joshua A.
[9] Miller, A. Raymond
[10] Hardy, James K.
[11] Reese, R. Neil
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Wyzgoski, F.J. (wyzgoski.1@osu.edu) | 1989年 / American Chemical Society卷 / 62期
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Black raspberry (Rubus occidentalis L.) (BR) fruit extracts with differing compound profiles have shown variable antiproliferative activities against HT-29 colon cancer cell lines. This study used partial least-squares (PLS) regression analysis to develop a high-resolution 1H NMR-based multivariate statistical model for discerning the biological activity of BR constituents. This model identified specific bioactive compounds and ascertained their relative contribution against cancer cell proliferation. Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside were the predominant contributors to the extract bioactivity; but salicylic acid derivatives (e.g; salicylic acid glucosyl ester); quercetin; 3-glucoside; 3-rutinoside; p-coumaric acid; epicatechin; methyl ellagic acid derivatives (e.g; methyl ellagic acetyl pentose); and citric acid derivatives also contributed significantly to the antiproliferative activity of the berry extracts. This approach enabled the identification of new bioactive components in BR fruits and demonstrates the utility of the method for assessing chemopreventive compounds in foods and food products. © 2014 American Chemical Society;
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