Chemical Composition Analysis of Yiqi Jiangzhi Granules Based on UPLC-LTQ Orbitrap MS

被引：0
|
作者：
Zhang Y. [1 ]
Hu S.-W. [1 ]
Yang J.-Y. [1 ]
Zhang J.-H. [1 ]
Wang L. [1 ]
Jiang L.-J. [1 ]
Jiang Y.-Y. [1 ]
Liu B. [1 ]
机构：
[1] School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing
来源：
Journal of Chinese Mass Spectrometry Society | 2020年 / 41卷 / 05期
关键词：
Alkaloids; Anthraquinones; Flavonoids; Ultra high performance liquid chromatography-linear ion trap/electrostatic orbitrap combined high resolution mass spectrometry (UPLC-LTQ Orbitrap MS); Yiqi Jiangzhi Granules;
D O I：
10.7538/zpxb.2019.0020
中图分类号：
学科分类号：
摘要：
In order to comprehensively understand the chemical composition of Yiqi Jiangzhi Granules, ultra-high performance liquid chromatography-linear ion trap/electro-static orbitrap combined high resolution mass spectrometry (UPLC-LTQ Orbitrap MS) was applied. By comparing the exacted molecular mass, retention time and mass spectrometry fragment ion information of each component to reference substance and related literature, a total of 97 chemical composition were identified, including flavonoids, alkaloids, phenolic acids, anthraquinones, triterpenoids, sesquiterpenoids and other components. Besides, tricin, tricin-7-O-glucoside, 8-acetyl-7-hydroxy-4-methylcoumarin and 3-acetylcoumarin were identified from the ten medicinal ingredients in Yiqi Jiangzhi prescription for the first time. Meanwhile, this study can provide a reference for the research of Yiqi Jiangzhi Granules quality control and pharmacodynamics development. © 2020, Editorial Board of Journal of Chinese Mass Spectrometry Society. All right reserved.
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页码：411 / 426
页数：15
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