Study on the preparation of drug-loaded composite for bone-repair and its effect on fracture-healing in rabbits

被引：0

作者：

Zhang, Qin ^{[1
]}

Gao, Wei ^{[1
]}

Zeng, Ren-Jie ^{[1
]}

Sun, Wei-Zhang ^{[1
]}

Tan, Ying-Jun ^{[1
]}

Zhang, Li-Ru ^{[1
]}

机构：

[1] Department of Pharmacy, General Hosp. Chengdu Command, Chengdu 610083, China

来源：

Chinese Pharmaceutical Journal | 2002年 / 37卷 / 02期

关键词：

Bone - Cellulose - Composite materials - Controlled drug delivery - Fracture - Plasticizers;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

OBJECTIVE: To prepare the composite with different amount of microcapsule and study the repair effect of the composite in rabbits. METHOD: Ethyl cellulose was used as the carrier and plasticizer to prepare the composite and repair of the artificial bone defect in rabbit was monitored. RESULTS: The plasticizer was used as the sustained-release carrier and improved the characteristics of the commercial material. CONCLUSION: The microcapsule was used as the drug carrier and plasticizer simultaneously. 3% microcapsule composite had the better bone-repair characteristics. The drug loaded in the composite had the sustained release profile.

引用

页码：113 / 115

共 12 条

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