Study on metabolites of mequindox in apostichopusjaponicus by HPLC-MS/MS

被引：0
|
作者：
Shandong Province Key Laboratory of Restoration for Marine Ecology, Shandong Marine Resource and Environment Research Institute, Yantai [1 ]
264006, China
不详 [2 ]
264006, China
不详 [3 ]
201306, China
机构：
来源：
J. Chin. Mass Spectrom. Soc. | / 5卷 / 417-424期
关键词：
Biomolecules - Electrospray ionization - Positive ions - High performance liquid chromatography - Acetonitrile - Mass spectrometry - Extraction;
D O I：
10.7538/zpxb.youxian.2015.0023
中图分类号：
学科分类号：
摘要：
Mequindox and its possible metabolites in body wall of Apostichopusjaponicus were identified by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Acetonitrile extraction and hydrochloric acid hydrolysis-SPE extraction were conducted to extract different kinds of metabolites. Metabolites were separated on an Acquity™ UPLC® BEH C18 (2.1 mm×50 mm×1.7 μm)column by gradient elution with acetonitrile-water (containing 0.1% formic acid) as mobile phase, and detected by positive ions electrospray ionization (ESI) mass spectrometry with fullscan-data dependent scan. Through comparison of MS1 and MS2 ions with the reference standard, 3-methyl-quinoxaline-2-carbosylic acid (MQCA) is identified as a metabolite of mequindox in Apostichopusjaponicus. The other identified metabolites include D2, D3, D4, and which the fragmentation pathways are deduced. ©, 2015, Chinese Society for Mass Spectrometry. All right reserved.
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