2-Substituted 4-(trifluoromethyl)phenols by directed ortho-lithiation

被引：0
|
作者：
Geneste, H. [1 ]
Schäfer, B. [1 ]
机构：
[1] Knoll GmbH, Postfach 210805, 67008 Ludwigshafen, Germany
来源：
Synthesis | 2001年 / 15期
关键词：
Catalyst selectivity - Hydroxylation - Phenols;
D O I：
10.1055/s-2001-18440
中图分类号：
学科分类号：
摘要：
A broad variety of 2-substituted 4-(trifluoromethyl)phenols can be prepared in a large scale by o-lithiation and reaction with electrophiles in good to excellent yields. The key for the selectivity is the superior ortho-directing effect of the THP-protected hydroxy group (OTHP) as compared to the CF3-group.
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页码：2259 / 2262
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