Allergenicity evaluation of an extensively hydrolyzed infant formula based on cow milk protein

被引：0

作者：

Li, Hongbo ^{[1
]}

Yang, Lin ^{[1
]}

Li, Jiayi ^{[1
]}

Gao, Quan ^{[1
]}

Liu, Tiantian ^{[2
]}

Zou, Yang ^{[3
]}

Chen, Xiaohong ^{[3
]}

Li, Hongjuan ^{[1
]}

Yu, Jinghua ^{[1
]}

机构：

[1] College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin,300457, China

[2] School of Food Science, Henan Institute of Science and Technology, Xinxiang,453003, China

[3] Tianjin Haihe Dairy Co. Ltd, No. 158, Jingwu Road, Tianjin Airport Economic Zone, Tianjin Economic-Technological Development Area (TEDA), Tianjin,300457, China

来源：

Food and Function | 2024年 / 15卷 / 22期

关键词：

Cow milk protein allergy (CMPA) is the most common food allergy in infants. Currently; hypoallergenic infant formulas on the market are mainly divided into extensively hydrolyzed whey protein formulas and extensively hydrolyzed casein formulas. There are few extensively hydrolyzed infant formulas (EHFs) with a similar protein composition to breast milk. Therefore; we developed a hypoallergenic infant formula based on extensively hydrolyzed cow milk protein (whey protein-to-casein ratio of 6 : 4) and evaluated its allergenicity in vitro and in vivo. The results showed that the antigenicity of EHF was significantly decreased. The levels of Treg and Th1 cells were increased; while the levels of Th2 cells; IgE and IgG1; plasma histamine and serum mast cell enzymes were significantly decreased. At the same time; the allergic symptoms of the jejunum and lungs of mice were relieved. This study provides a solution for the development of cow milk protein based hypoallergenic infant formulas. © 2024 The Royal Society of Chemistry;

D O I：

10.1039/d4fo03582h

中图分类号：

学科分类号：

摘要：

引用

页码：11036 / 11046

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