A Review of Delta- Sleep-Inducing Peptide

Delta sleep-inducing peptide (DSIP) was the first sleep-factor whose chemical structure has been identified. Synthesis of DSIP by means of various methods, such as solution method, solid phase method, enzymatic promotion method and genetic engineering method, was discussed. Some new biological activities other than the somnogenic effect of DSIP were introduced. The structure-activity relationship (SAR) of DSIP and conformational study of this peptide in solution were also presented. Some approaches of further studies on DSIP were suggested.