Anti-mutagenic of Salvianolic Acid A, B and Catechu Aldehyde Using Comet Assay and Micronucleus Assay

被引：0
|
作者：
Ding Y. [1 ,2 ]
Zhang L. [1 ]
Wang J. [1 ,3 ]
Zhang K. [1 ]
Wang F. [1 ]
Xiao W. [3 ]
Zhu J. [1 ,2 ]
机构：
[1] College of Food Science, Dalian Polytechnic University, Dalian, 116034, Liaoning
[2] National Engineering Research Center of Seafood, Dalian, 116034, Liaoning
[3] Jiangsu Kanion Pharmaceutical CO., Ltd, Lianyungang, 222001, Jiangsu
来源：
Journal of Chinese Institute of Food Science and Technology | 2018年 / 18卷 / 09期
关键词：
Catechu aldehyde; Comet assay; Micronucleus assay; Salvianolic acid A; Salvianolic acid B;
D O I：
10.16429/j.1009-7848.2018.09.040
中图分类号：
O62 [有机化学]; TQ [化学工业];
学科分类号：
070303 ; 0817 ; 081704 ;
摘要：
In our preliminary screening study on the anti-mutagenic activity, two phenolic acids and one aldehyde were isolated from the Salvia miltiorrhiza. On the basis of their spectroscopic data, these compounds were identified as Salvianolic acid A (1), Salvianolic acid B (2) and Catechu aldehyde (3). Among the compounds that were tested, Sal B showed dose-dependently inhibitory activity of the tail moment with the percentage of migrated DNA of 90.4%(P<0.01) in the concentration of 100 μg/mL. Sal A and CA showed dose-dependently activity to inhibit the micronuclei rate to 33.3% (P<0.01) and 35.1% (P<0.01), respectively, in the concentration of 100 μg/mL. © 2018, Editorial Office of Journal of CIFST. All right reserved.
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页码：311 / 316
页数：5
相关论文
共 18 条
  • [1] Lu Y., Foo L.Y., Polyphenolics of Salvia-A review, Phytochemistry, 59, 2, pp. 117-140, (2002)
  • [2] Lin H.C., Chang W.L., Diterpenoids from Salvia miltiorrhiza, Phytochemistry, 53, pp. 951-953, (2000)
  • [3] Liu Y.R., Qu S.X., Maitz M.F., Et al., The effect of the major components of Salvia Miltiorrhiza Bunge on bone marrow cells, Journal of Ethnopharmacology, 111, 3, pp. 573-583, (2007)
  • [4] Ji X.Y., Tan B.K.H., Zhu Y.C., Et al., Comparison of cardioprotective effects using ramipril and Danshen for the treatment of acute myocardial infarction in rats, Life Science, 73, 11, pp. 1413-1426, (2003)
  • [5] Fei Y.J., Kou Z.N., Wang Y.Y., Et al., Comprehensive extraction of active components from Radix salviae miltiorrhiza, Dalian Polytechnic University, 6, pp. 35-38, (2009)
  • [6] Birosova L., Mikulasova M., Vaverkova S., Antimutagenic effect of phenolic acids, Biomedical Papers, 149, 2, pp. 489-491, (2005)
  • [7] Kagan V.E., Tyurinov Y.Y., Recycling and redox cycling of phenolic antioxidants, Annals of the New York Academy of Sciences, 854, 1, pp. 425-434, (2010)
  • [8] Zhou Y.C., Zheng R.L., Phenolic compounds and an analog as superoxide anion scavengers and antioxidants, Biochemical Pharmacology, 42, 6, pp. 1177-1179, (1991)
  • [9] Kono Y., Shibata H., Kodama Y., Et al., The suppression of the N-nitrosating reaction by chlorogenic acid, Biochemical Journal, 312, 3, pp. 947-953, (1995)
  • [10] Brune M., Rossander L., Hallerg L., Iron absorption and phenolic compounds: importance of different phenolic structures, European Journal of Clinical Nutrition, 43, 8, pp. 547-557, (1989)
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