A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

被引：0
|
作者：
Li Y. [1 ,2 ]
He H. [2 ]
Lu W. [3 ]
Jia X. [2 ]
机构：
[1] College of Materials Science and Engineering, Hebei University of Engineering, Handan
[2] Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry, Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing
[3] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing
来源：
Lu, Wanliang (luwl@bjmu.edu.cn) | 2017年 / Royal Society of Chemistry卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Tumors - Molecular biology - Controlled drug delivery - Targeted drug delivery;
D O I：
10.1039/C7RA00713B
中图分类号：
学科分类号：
摘要：
A drug delivery carrier G4-FA-PEG with PEG and FA modified on the periphery of G4.0 poly(amidoamine) (PAMAM) dendrimer was synthesized, and doxorubicin (DOX) was encapsulated in the interior. The in vitro cytotoxicity and cellular uptake in gliomas cells were both enhanced via a FR-mediated endocytosis pathway. © The Royal Society of Chemistry.
引用
收藏
页码：15475 / 15481
页数：6
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