Study on pH Responsive Nanomedicine in Chemo-photothermal Synergistic Therapy of Tumor

被引：0
|
作者：
Tang Z. [1 ]
Tian W. [1 ]
机构：
[1] School of New Energy and Materials, Southwest Petroluem University, Chengdu
来源：
Cailiao Daobao/Materials Reports | 2022年 / 36卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Chemotherapy; Near-infrared; Photothermal therapy; Synergistic effect;
D O I：
10.11896/cldb.21120187
中图分类号：
学科分类号：
摘要：
Chemotherapy (CT) combined with photothermal therapy (PTT) is an effective combination for the treatment of tumor. Herein, we deve-loped a subcellular-targeted NIR-responsive nanomedicine Fe3O4@PDA-TPP/S2-PEG-hyd-DOX (abbreviated as Fe3O4-ATSPD) as a new photothermal agent, the intracellular uptake of which can be enhanced by magnetic targeting. Under the near-infrared (NIR) irradiation, the photothermal effect can be realized from the polydopamine photosensitizer, leading to a dramatic decrease in mitochondrial membrane potential. Simultaneously, the conjugated drugs released by low pH in endo/lysosome cause nucleus DNA damage and lead to apoptosis. This subcellular-targeted NIR-responsive nanomedicine with efficient integration of diagnosis and therapy, could significantly enhance cancer treatment by combination of chemotherapy and PTT. © 2022, Materials Review Magazine. All right reserved.
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