Preparation and Characterization of Hydroxyapatite-Pectin Composite Nanoparticles

被引：0
|
作者：
Yao F. [1 ]
Luo Q. [1 ]
Guo Q. [1 ]
Tian L. [1 ]
Li J. [1 ]
机构：
[1] School of Chemical Engineering and Technology, Tianjin University, Tianjin
来源：
Tianjin Daxue Xuebao (Ziran Kexue yu Gongcheng Jishu Ban)/Journal of Tianjin University Science and Technology | 2020年 / 53卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Biomaterial; Biomineralization; Hydroxyapatite; Nanoparticle; Pectin;
D O I：
10.11784/tdxbz201903004
中图分类号：
学科分类号：
摘要：
Hydroxyapatite (HAp) has potential applications in bone tissue engineering and drug delivery because of its excellent biocompatibility and osteoinductivity. Compared with traditional HAp particles, nano-HAp has several advantages, such as high specific surface area, high surface energy, and targeted properties. Moreover, it has excellent protein adsorption capacity because of its high surface roughness and high hydrophilicity. By contrast, pure HAp is prone to agglomeration; this unstable behavior is inconducive to cell uptake and may also cause vascular blockage, further hindering its application in vivo. Pectin is a heteropolysaccharide derived from the cell wall of plants. It has been widely used in food and medicine because of its good biosafety and gelling properties. Recently, it has attracted considerable attention in tissue engineering. In this study, hydroxyapatite-pectin composite (HAp@pectin) nanoparticles are prepared and their properties are investigated. First, pectin/calcium nanogel is obtained through the forces of interactions between carboxyl groups in pectin and calcium ions (Ca2+). Then, HAp@pectin nanoparticles form in situ after phosphate is introduced. Additionally, the structures and interactions in the HAp@pectin system are investigated via FT-IR, XRD and TGA. The morphology of HAp@pectin is modulated by adjusting the ratio of calcium to phosphate. The morphology is evaluated via transmission electron microscopy, and the size and zeta-potential are investigated using a laser particle size analyzer. The results indicate that the electrostatic interactions between pectin and HAp are the main driving force behind the formation of HAp@pectin. Moreover, the morphology and size can be modulated by adjusting the percentage of pectin in the system. These findings indicate that effective biomaterials based on natural polysaccharides and nano-HAp can be developed. © 2020, Editorial Board of Journal of Tianjin University(Science and Technology). All right reserved.
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页码：279 / 283
页数：4
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