Dynamics of Escherichia coli population expressing heterologous proteins

被引：0
|
作者：
Gogulancea, Valentina [1 ]
Isopencu, Gabriela [1 ]
Ferdes, Mariana [1 ]
Ofieru, Irina Dana [1 ]
Lavric, Vasile [1 ]
机构：
[1] Dept. of Chemical and Biochemical Engineering, University POLITEHNICA of Bucharest, Romania
来源：
UPB Scientific Bulletin, Series B: Chemistry and Materials Science | 2015年 / 77卷 / 01期
关键词：
Bacterial population - Bioprocesses - Downstream-processing - Expression of heterologous proteins - Heterologous proteins - Recovery and purifications - Used systems;
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学科分类号：
摘要：
Expression of heterologous proteins in Escherichia coli is an important and highly used system for obtaining large quantities of recombinant proteins for a wide range of applications in biotechnologies, medicine etc. However, the ability for delivering high quantities of recombinant proteins at desired quality and the cost effectiveness of the process is under serious scrutiny. Most improvements on bioprocesses for recombinant proteins production are focused on downstream processing, like primary recovery and purification. The present work relies on monitoring the bacterial population development and dynamics in the bioreactor, and presents the premises for modelling and optimization.
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页码：87 / 94
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