Neuroprotective effects of soy isoflavones on PC12 cells based on antioxidation

被引：0

作者：

Xu M.-L. ^{[1
]}

Gao Y. ^{[2
]}

Liu J.-B. ^{[1
]}

Xiong J.-F. ^{[3
]}

Zhao S.-N. ^{[1
]}

Huang Y.-J. ^{[1
]}

机构：

[1] Laboratory of Nutrition and Functional Food, Jilin University, Changchun

[2] College of Agriculture, Jilin Agricultural University, Changchun

[3] Changchun Institute of Biological Products Co., Ltd., Changchun

来源：

Liu, Jing-Bo (ljb168@sohu.com) | 1600年 / Editorial Board of Jilin University卷 / 47期

关键词：

Antioxidant; Daidzein; Food processing technology; Genistein; Neuroprotective effect; PC12; cells; Soy isoflavones;

D O I：

10.13229/j.cnki.jdxbgxb201701048

中图分类号：

学科分类号：

摘要：

Experiment results show that when PC12 cells were exposed to 20.00 μg/mL genistein (GEN), daidzein (DAI) or their combination (GEN-DAI), the cells' viability rates, mophologies, mitochondrial membrane potential, superoxide dismutase activities and inhibition rates were not changed. However, different changes of PC12 cells were observed under different treatments. The reactive oxygen species level, the relative fluorescence intensity and malondialdehyde of PC12 cells were increased by GEN. The leakage rate of lactic dehydrogenase was decreased in DAI and in GEN-DAI combination treatments, the glutathione contents were increased to (297.27±9.47) μmol/(g·prot) and (269.90±00) μmol/(g·prot) respectively. The acetylcholine content in culture medium and metabolism of cholinergic system was increased in GEN-DAI treatment. GEN-DAI combination treatment can more significantly increase the activity of the antioxidant system of PC12 cells than GEN and DAI treatments. © 2017, Editorial Board of Jilin University. All right reserved.

引用

页码：332 / 336

页数：4

共 12 条

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