Fabrication and Characterization of Photo-Crosslinked Poly(L-glutamic acid) Hydrogels

被引：0
|
作者：
Wang B. [1 ]
Li G. [1 ]
Zong H. [1 ]
Yan S. [1 ]
Yin J. [1 ]
机构：
[1] Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai
来源：
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | 2020年 / 36卷 / 01期
关键词：
Biocompatibility; Photo-crosslinking hydrogel; Poly (L-glutamic acid); Polyethylene glycol acrylate;
D O I：
10.16865/j.cnki.1000-7555.2020.0010
中图分类号：
学科分类号：
摘要：
The poly(L-glutamic acid) (PLGA) graft polymer PLGA-g-APEG with a side-linked polyethylene glycol acrylate (APEG) was used as precursor, and the hydrogel was prepared by UV-crosslinking. Then the effects of grafting ratio of APEG and mass concentration of the precursor on the mechanical properties of photocrosslinked hydrogels were studied. When the grafting ratio of APEG reaches 44.7% and the mass fraction of PLGA-g-APEG reaches 15%, the mechanical properties of hydrogel achieve the best. The storage modulus is 16238.2 Pa, and the compressive failure stress is 0.16 MPa. At the same time, the hydrogel was subjected to several cycles of compression test. The results show that the cyclic compression curves are almost completely coincident, the hydrogel has excellent resilience performance. Finally, the results of MTT and the dead/live experiments show that the PLGA-g-APEG precursor and its photocrosslinked hydrogel have good biocompatibility, the hydrogel has potential application in the fields of regenerative medicine. © 2020, Editorial Board of Polymer Materials Science & Engineering. All right reserved.
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页码：126 / 133
页数：7
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