Preparation of Fe3O4-10-HCPT and Fe3O4-HCPT@SiO2 core-shell nanoparticles

To effectively control the dispersion and avoid the aggregate of Fe3O4 nanoparticles in the water, the dispersion of Fe3O4 nanoparticles was investigated before and after ultrasonic bath in different concentration of NaCl solution. The experimental results showed that the dispersion of Fe3O4 nanoparticles was little of aggeregates in the 0.4 mol/L NaCl solution. Furthermore, the magnetic Fe3O4-10-Hydroxycamptothecin compounds were prepared by refining pH values of 10-Hydroxycamptothecin system, and then the Fe3O4-HCPT@SiO2 core-shell structural nanoparticles were prepared, of which the diameter of the composite nanoparticle is about 120 nm. The drug release process proves the feasibility of this preparation method. ©, 2015, Harbin Institute of Technology. All right reserved.