Linkage disequilibrium analysis of chromosome 22 and schizophrenia in a Chinese population

被引：0
|
作者：
Cai, G. [1 ]
Li, T. [1 ]
Deng, H. [1 ]
Wu, M. [1 ]
Liu, X. [1 ]
Collier, D.A. [1 ]
机构：
[1] Institute of Mental Health, First Affiliated Hospital, West China Univ. of Medical Sciences, Chengdu, Sichuan 610041, China
来源：
Chinese Journal of Medical Genetics | 2001年 / 18卷 / 05期
关键词：
Chromosomes; -; Fluorescence;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: To explore the molecular genetic relations of chromosome 22 and schizophrenia and locate the susceptibility gene of schizophrenia. Methods Six dinucleotide tandem repeat loci on chromosome 22 were chosen to analyze 126 affected sib-pair nuclear families of schizophrenia in Chinese population by fluorescent labeled auto-mated genotyping and transmission/disequilibrium test (TDT). Results: The TDT-χ2 value of IL2Rβ was 25.30 (P= 0.01), which suggests there is linkage disequilibrium between IL2Rβ and schizophrenia. The P vaules of the other five loci (D22S944, D22S264, D22S303, D22S278 and CYP2D6) were greater than 0.05. Conclusion: A susceptive gene of schizophrenia may be located in IL2Rβ locus or adjacent region.
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页码：335 / 337
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