Wound Healing Activity of Ipomoea staphylina Leaves Extract in Wistar Rats

被引：0
|
作者：
Lu, Manjun [1 ]
Yang, Hongchao [2 ]
Yang, Na [3 ]
Peng, Jun [4 ]
Hou, Xiuli [4 ]
机构：
[1] Plastic and Cosmetic Surgery, Qilu Hospital of Shandong University Dezhou Hospital (Dezhou People’s Hospital), Dezhou,253000, China
[2] Department of Pediatric Surgery, Qilu Hospital Of Shandong University Dezhou Hospital (Dezhou People’s Hospital), Dezhou,253000, China
[3] Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University Dezhou Hospital (Dezhou People’s Hospital), Dezhou,253000, China
[4] Department of Dermatology, Qilu Hospital of Shandong University Dezhou Hospital (Dezhou People’s Hospital), Dezhou,253000, China
来源：
BioResources | 2024年 / 19卷 / 04期
关键词：
Wound repair is the practice of repairing the skin and other soft tissues after an injury. An inflammatory response is activated after an injury; and cells below the dermis (deepest skin layer) begin to produce more collagen (connective tissue). A scientific assessment was made for the wound-healing potential of Ipomoea staphylina leaves extract; using ethanol. The crude extract was made into a 2.5% and 5% (w/w) ointment and tested for wound healing activity in Wistar rats using excision and incision wound models. In the excision wound model; the period of epithelialization was reduced and an increase in wound contraction rate was observed in the extract treated groups (III and IV). On the tenth day; tissue from the excision wound area was taken and processed for the assessment of pro-inflammatory cytokines (TNF-α); and it was found that there was a notable decrease in the TNF-α concentration in the extract-treated animals. In an incision wound model; the breaking strength was significantly increased in animals treated with 2.5% and 5% (w/w) ointment of I. staphylina leaves extract. The extract significantly promoted fibroblast migration in an in vitro experiment (scratch assay); which may have been caused by the presence of flavonoids. © 2024; North Carolina State University. All rights reserved;
D O I：
10.15376/biores.19.4.9220-9233
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页码：9220 / 9233
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