Research Progress on Antitumor Mechanism of 6-Shogaol

被引：0
|
作者：
Wang Z. [1 ,2 ]
Hu H. [3 ]
Chen Q. [2 ]
Zhou J. [2 ]
Ren Z. [3 ]
Jiang L. [1 ,2 ,3 ]
机构：
[1] College of Light Industry and Food Engineering, Guangxi University, Nanning
[2] Medical College, Guangxi University, Nanning
[3] School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise
来源：
Science and Technology of Food Industry | 2023年 / 44卷 / 11期
关键词：
6-shogaol; anti-tumor; mechanism of action; research progress;
D O I：
10.13386/j.issn1002-0306.2022080339
中图分类号：
学科分类号：
摘要：
The incidence and mortality of cancer are increasing year by year, which seriously threatens human health. 6-Shogaol, as one of the main active components in ginger, has become the focus of attention in recent years due to its advantages of safety and low toxicity. Moreover, it has anti-inflammatory, antioxidant, anti-tumor and other pharmacological effects. Particularly, its anti-tumor activity has received increasing attention. This paper reviews the antitumor mechanism of 6-shogaol, including inhibition of cell proliferation, induction of cell apoptosis, arrest of cell cycle, inhibition of cell migration and invasion, effect of autophagy in tumor cells, etc., in order to provide ideas for further research, development and application of 6-shogaol in anti-tumor. © 2023 Science and Technology of Food Industry. All rights reserved.
引用
收藏
页码：480 / 486
页数：6
相关论文
共 65 条
  • [1] FERLAY J, COLOMBET M, SOERJOMATARAM I, Et al., Cancer statistics for the year 2020: An overview[J], International Journal of Cancer, (2021)
  • [2] CAO W, CHEN H D, YU Y W, Et al., Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020[J], Chinese Medical Journal (England), 134, 7, pp. 783-791, (2021)
  • [3] MOHD Y Y A., Gingerol and its role in chronic diseases[J], Advances in Experimental Medicine and Biology, 929, pp. 177-207, (2016)
  • [4] MARX W, RIED K, MCCARTHY A L, Et al., Ginger-mechanism of action in chemotherapy-induced nausea and vomiting: A review[J], Critical Reviews in Food Science and Nutrition, 57, 1, pp. 141-146, (2017)
  • [5] SEMWAL R B, SEMWAL D K, COMBRINCK S, Et al., Gingerols and shogaols: Important nutraceutical principles from ginger [J], Phytochemistry, 117, pp. 554-568, (2015)
  • [6] KOU X, LI X Z, RAMIM T R, Et al., Efficient dehydration of 6-gingerol to 6-shogaol catalyzed by an acidic ionic liquid under ultrasound irradiation[J], Food Chemistry, 215, pp. 193-199, (2017)
  • [7] ZHANG Y, WANG J J, QU Y, Et al., 6-Shogaol suppresses the progression of liver cancer via the inactivation of Wnt/Catenin signaling by regulating TLR4[J], American Journal of Chinese Medicine, 49, 8, (2021)
  • [8] BAWADOOD A S, ABBASI F A, ANWAR F, Et al., 6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway[J], Biomedicine & Pharmacothertpy, 128, (2020)
  • [9] WU C H, HONG B, HO C T, Et al., Targeting cancer stem cells in breast cancer: Potential anticancer properties of 6-shogaol and pterostilbene[J], Journal of Agricultural and Food Chemistry, 63, 9, pp. 2432-2441, (2015)
  • [10] HUANG H, KIM M K, KIM K R., Anticancer effects of 6-shogaol via the AKT signaling pathway in oral squamous cell carcinoma[J], Journal of Applied Oral Science, 29, (2021)
1234567