Catalytic Atroposelective Construction of Furan-Based Axially Chiral Scaffolds

Axially chiral furan-based scaffolds have been recognized as a class of important five-membered heteroaryl atropisomers, and developing catalytic atroposelective reactions for constructing this class of scaffolds is highly desirable. However, the catalytic atroposelective construction of such scaffolds is rather underdeveloped due to the existence of great challenges such as remote ortho-substituents and weak configurational stability. To overcome these challenges, synthetic chemists have recently paid great attention to this research field, and a number of axially chiral furan-based scaffolds have been constructed via catalytic atroposelective reactions using different strategies. This concept summarized these advances in this field and pointed out the remaining challenges, which will promote the further development of this emerging field.