Progress in the Development of Detection Methods for Amantadine Residues in Foods

被引：0

作者：

Peng J. ^{[1
]}

Lai K. ^{[1
]}

机构：

[1] State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang

来源：

Shipin Kexue/Food Science | 2021年 / 42卷 / 19期

关键词：

Amantadine; Food; Immunoassay; Liquid chromatography-mass spectrometry; Molecular imprinting;

D O I：

10.7506/spkx1002-6630-20200916-198

中图分类号：

学科分类号：

摘要：

Amantadine (AMD), an antiviral agent, can cause a threat to consumers' health when abused. Although AMD has been banned from being used in livestock and poultry in many countries including the USA and China, it is still being used illegally. This article presents a brief introduction to the physicochemical properties and hazards of amantadine, some incidences related to amantadine residues in meat and eggs, the latest standards and the commonly used methods for AMD detection. High performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), enzyme-linked immunosorbent assay (ELSA), immunochromatography, and chemiluminescence immunoassay have been traditionally and widely used for the detection of AMD. Novel immunoassays based on antigen-antibody reaction and molecular imprinting methods based on structural features of amantadine are attracting growing attention and may be used in the future. © 2021, China Food Publishing Company. All right reserved.

引用

页码：325 / 333

页数：8

共 39 条

[1] REN Yizhong, LI Chufang, FENG Liqiang, Et al., Proton channel activity of influenza a virus matrix protein2 contributes to autophagy arrest, Journal of Virology, 90, 1, pp. 591-598, (2016)
[2] ILYUSHINA N A, BOVIN N V, WEBSTER R G, Et al., Combination chemotherapy, a potential strategy for reducing the emergence of drugresistant influenza a variants, Antiviral Research, 70, 3, pp. 121-131, (2006)
[3] WAN Xiufeng, CARREL M, LONG Liping, Et al., Perspective on emergence and re-emergence of amantadine resistant influenza a viruses in domestic animals in China[J], Infection Genetics and Evolution, 20, pp. 298-303, (2013)
[4] (2012)
[5] (2014)
[6] (2016)
[7] (2019)
[8] (2015)
[9] (2007)
[10] (2016)

← 1 2 3 4 →