Preparation and characterization of Basil essential oil nanoparticles/polyvinylpyrrolidone-polyvinyl alcohol hydrogel wound dressing

被引：0
|
作者：
Xu M. [1 ]
Zhang L. [1 ]
He Z. [2 ]
机构：
[1] School of Chemistry and Chemical Engineering, Xi'an University of Architecture and Technology, Xi'an
[2] Analysis and Test Center, Xi'an University of Architecture and Technology, Xi'an
来源：
Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica | 2024年 / 41卷 / 02期
基金：
中国国家自然科学基金;
关键词：
antibacterial activity; Basil essential oil nanoparticles; hydrogel; nanoprecipitation method; wound dressing;
D O I：
10.13801/j.cnki.fhclxb.20230629.002
中图分类号：
学科分类号：
摘要：
Basil essential oil (BEO) is a green and safe antibacterial agent. However, the high volatility of BEO has limited its application in the field of antibacterial wound dressings. BEO nanoparticles (BEO@Zein) were prepared by nanoprecipitation method. They were then loaded on the hydrogel based on polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) to form BEO@Zein/PVP-PVA hydrogel wound dressing by freeze-thaw cycle. The microscopic morphology and structure of BEO@Zein and hydrogel were characterized. The antibacterial property, mechanical property, swelling and moisturizing, degradability and blood compatibility of hydrogel were studied. The results show that BEO@Zein forms a nano-spherical structure with BEO as core and Zein as shell (mean particle size is 56.3 nm), which significantly reduces the volatility of BEO. BEO@Zein/PVP-PVA hydrogel can release BEO slowly, thus exhibiting excellent slow-release antibacterial property. Therefore, BEO@Zein/PVP-PVA hydrogel has excellent antimicrobial persistence (over 72 h). In addition, the hydrogel shows remarkable antibacterial biofilm property. BEO@Zein/PVP-PVA hydrogel has good mechanical property, swelling and moisturizing, degradability, and blood compatibility. Studies have shown that BEO@Zein/PVP-PVA hydrogel can be used as a good wound dressing material. © 2024 Beijing University of Aeronautics and Astronautics (BUAA). All rights reserved.
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页码：748 / 760
页数：12
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